Abstract: The recognition that HIV prevention materials need to be adapted to local cultures is not often sufficiently understood and applied. Counter discourses and determined disputation about the best means of HIV prevention show that success is not simply a matter of mindfully translating globally sanctioned knowledge and presenting it to receptive audiences. Beliefs contrary to global AIDS knowledges will not be displaced inevitably by scientific facts. As this study of born-again Christians in Papua New Guinea shows, there is incommensurability between the globalized approach preferred by the government and the approach of these Christians. The answer may lie in two words: respect and dialogue.